Method of visualising and analysing particles in liquids, from 10-2000nm, operates by relating rate of Brownian motion to particle size. Parameters that influence results include viscosity of the liquid, the temperature and size of the particle - not influenced by particle density or refractive index. Particles contained in a sample are visualised by virtue of the light they scatter when illuminated by laser light. Typical analysis time is approximately 30s however longer analysis times improve accuracy and statistics. Can give approximate concentration of particles and is excellent for determining state of dispersion / aggregation of particles in solution. Applications include analysis of biological and synthetic vesicles, drug delivery vehicles, various nanomaterials and protein aggregation.
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